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Slight (one)disulfiram will increase toxicity of metronidazole topical by decreasing metabolism. Minor/Significance Unknown. Enhanced CNS & cardiac toxicity with oral metronidazole and disulfiram; not as likely to occur with topical administration as a result of reduced absorption.
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Disulfiram-like reaction to alcohol has long been noted with oral metronidazole, thus the opportunity of this type of reaction developing whilst on metronidazole vaginal gel therapy cannot be excluded.
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